has announced that its lead asset iclaprim will be evaluated in a study funded by the National Institutes of Health (NIH), the United States’ leading governmental biomedical research center, as a possible treatment for listeria.
The National Institute of Allergy and Infectious Diseases, which like the NIH falls under the US Department of Health & Human Services, will provide Motif Bio with preclinical services through JMI Laboratories.
The study follows earlier in vitro testing which showed iclaprim was more than 32-fold more potent than standard-of-care treatments.
Shares in Motif Bio are up 13% at 2.60 pence each this morning.
Listeriosis is a rare but serious infection caused by eating contaminated foods that afflicts around 1,600 people in the US each year. If not properly treated, listeriosis can devolve into septicaemia or meningitis, and can be, in some cases, fatal.
David Huang, M.D., Ph.D., Chief Medical Officer of Motif Bio, commented on the news: "Listeriosis is a potentially life-threatening infection for which more effective treatment options are needed.
If the results of this study confirm that iclaprim has potent activity against L. monocytogenes, we believe that iclaprim could be a potentially useful treatment option and would warrant further study."
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