Redx Pharma completes first dose of cancer drug RXC004 in first-phase study
Francesca Morgan
Company News - 2 mins
10:44, 19th August 2019

Redx Pharma (REDX) FOLLOW, the drug discovery company focused on cancer and fibrosis, announced on Monday that it had successfully completed dosing on its first cohort of patients undergoing its clinical trial of leading cancer drug, RXC004. 

The first-in-man clinical trial for RXC004 is a phase ½ study whose primary objective is to evaluate the safety and tolerability of the drug in patients with malignancies. 

RXC004 is known as a porcupine inhibitor, a key enzyme in the Wnt signalling pathway which is implicated in the maintenance of cancer stem cells in multiple cancer types. 

Adhering to protocol, the first part of the study entailed the first cohort of patients being administered a dose of 0.5mg. Following a review of the data based on the first cohort given by the Safety Review Committee, the recommendation has been made to now escalate the dose.

Shares in Redx Pharma perked up over 8% following this morning's news. 

The AIM-listed firm said recruitment of the second cohort of patients, who will be administered the drug at a higher pre-specified dose RXC004, has already begun.

Lisa Anson, Chief Executive Officer of Redx Pharma commented, "We are pleased that the Safety Review Committee  has  recommended that we can now escalate the dose in the phase 1 /2 study of RXC004 our oral porcupine inhibitor, and consequently we have begun enrolment of our second cohort of patients as per protocol.

We believe that RXC004 has the potential to offer clinical benefit both as a monotherapy and in combination with standard of care treatments for patients with Wnt-driven advanced solid tumours.” 

Ms Anson further added, “We look forward to completing patient enrolment for the phase 1 monotherapy dose-escalation study and announcing results during 2020." 

For more News & Updates on Redx Pharma: FOLLOW

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